Osteoporosis is a common and serious complication of GC therapy, resulting in increased risk of fragility fractures (1). Increased osteocyte lacunar size with a loss of perilacunar mineral along with the osteocytic autophagy were observed during GC treatment, suggesting that the osteocytes are metabolically stressed or compromised (2). Additionally, we propose that osteocytes can release extracellular vesicles or exosomes as an alternative mechanism for intercellular communication. Interestingly, it has been shown that an inverse relationship exists between the autophagic and exosomal pathways. Thus it would be interesting to determine whether GC treatment which favours autophagy in osteocytes results in decrease osteocytic exosome released. In addition to the molecular deciphering of the signalling events leading to GC-induced osteocyte autophagy, the potential interplay between autophagy and osteocyte exosome secretion will be the subject of investigation in this project.